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Journal of Applied Physiology, 121 (5), 10471052

2013;110(22):9066-9071 doi:10.1073/pnas.1219451110 (Animal) Depommier C, Everard A, Druart C, et al

This approach balances therapeutic benefits against theoretical concerns about long-term continuous use, for which we lack human safety data

Many patients with irregular sleep schedules, shift work disruptions, or jet lag patterns find DSIP helpful for recalibrating their natural sleep timing over time